Journal article

Pathophysiology of Major Depression by Clinical Stages

Ana Cecilia de Menezes Galvao, Raissa Nobrega Almeida, Geovan Menezes de Sousa, Mario Andre Leocadio-Miguel, Fernanda Palhano-Fontes, Draulio Barros de Araujo, Bruno Lobao-Soares, Joao Paulo Maia-de-Oliveira, Emerson Arcoverde Nunes, Jaime Eduardo Cecilio Hallak, Felipe Barreto Schuch, Jerome Sarris, Nicole Leite Galvao-Coelho

FRONTIERS IN PSYCHOLOGY | FRONTIERS MEDIA SA | Published : 2021

Abstract

The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first episode of MDD (n = 30) ..

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University of Melbourne Researchers

Grants

Awarded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil (CAPES)


Awarded by Brazilian National Council for Scientific and Technological Development (CNPq)


Awarded by CAPES Foundation within the Brazilian Ministry of Education


Awarded by CAPES Foundation from Brazilian Ministry of Education


Awarded by NHMRC Clinical Research Fellowship


Funding Acknowledgements

This study was financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil (CAPES) - Finance Code 001. This study was funded by the Brazilian National Council for Scientific and Technological Development (CNPq, Grant Nos. 466760/2014 and 479466/2013) and CAPES Foundation within the Brazilian Ministry of Education (Grant Nos. 1677/2012 and 1577/2013). NG-C and AM were supported by the CAPES Foundation from Brazilian Ministry of Education (Research Fellowship 88887.466701/201900 and 88882.344060/2019-01, respectively). JS was funded by an NHMRC Clinical Research Fellowship (APP1125000).