Risk Prediction Using Polygenic Risk Scores for Prevention of Stroke and Other Cardiovascular Diseases
Gad Abraham, Loes Rutten-Jacobs, Michael Inouye
STROKE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
Early prediction of risk of cardiovascular disease (CVD), including stroke, is a cornerstone of disease prevention. Clinical risk scores have been widely used for predicting CVD risk from known risk factors. Most CVDs have a substantial genetic component, which also has been confirmed for stroke in recent gene discovery efforts. However, the role of genetics in prediction of risk of CVD, including stroke, has been limited to testing for highly penetrant monogenic disorders. In contrast, the importance of polygenic variation, the aggregated effect of many common genetic variants across the genome with individually small effects, has become more apparent in the last 5 to 10 years, and powerful..View full abstract
Awarded by UK Medical Research Council
Awarded by British Heart Foundation
Dr Inouye was supported by the Munz Chair of Cardiovascular Prediction and Prevention. This work was supported by the Victorian Government's Operational Infrastructure Support (OIS) program, and by core funding from: the UK Medical Research Council (MR/L003120/1), the British Heart Foundation (RG/13/13/30194; RG/18/13/33946) and the National Institute for Health Research (Cambridge Biomedical Research Centre at the Cambridge University Hospitals NHS Foundation Trust; *). This work was supported by Health Data Research UK, which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), and the British Heart Foundation. *The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.