Journal article

Cannabis and tobacco use prior to pregnancy and subsequent offspring birth outcomes: a 20-year intergenerational prospective cohort study

Lindsey A Hines, Elizabeth A Spry, Margarita Moreno-Betancur, Hanafi Mohamad Husin, Denise Becker, Melissa Middleton, Jeffrey M Craig, Lex W Doyle, Craig A Olsson, George Patton



There is increasing evidence that the life-course origins of health and development begin before conception. We examined associations between timing and frequency of preconception cannabis and tobacco use and next generation preterm birth (PTB), low birth weight (LBW) and small for gestational age. 665 participants in a general population cohort were repeatedly assessed on tobacco and cannabis use between ages 14-29 years, before pregnancy. Associations were estimated using logistic regression. Preconception parent (either maternal or paternal) daily cannabis use age 15-17 was associated with sixfold increases in the odds of offspring PTB (aOR 6.65, 95% CI 1.92, 23.09), and offspring LBW (aO..

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Awarded by Australian Research Council

Awarded by NHMRC

Awarded by Wellcome Trust

Funding Acknowledgements

This work was supported by the Australian Research Council (DP180102447). Data collection for VIHCS was supported by the National Health and Medical Research Council; Australian Rotary Health; Colonial Foundation; Perpetual Trustees; Financial Markets Foundation for Children (Australia); Royal Children's Hospital Foundation; and the Murdoch Children's Research Institute. GP is supported by an NHMRC Senior Principle Research Fellowship (APP1117873). Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Program. This research was funded in whole, or in part, by the Wellcome Trust 209158/Z/17/Z (LH). For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.