Journal article

Cortisol Levels in Childhood Associated With Emergence of Attenuated Psychotic Symptoms in Early Adulthood.

Alexis E Cullen, Helen L Fisher, Nancy Gullet, Elizabeth R Fraser, Ruth E Roberts, Uzma Zahid, Melody To, Natalie Huijing Yap, Patricia A Zunszain, Carmine M Pariante, Stephen J Wood, Philip McGuire, Robin M Murray, Valeria Mondelli, Kristin R Laurens

Biol Psychiatry | Elsevier BV | Published : 2021

Abstract

BACKGROUND: In individuals at clinical high-risk for psychosis, elevated cortisol levels predict subsequent onset of psychotic disorder. However, it is unclear whether cortisol alterations are evident at an earlier clinical stage and promote progression of psychosis expression. This study aimed to address this issue by investigating whether cortisol levels in childhood were associated with the emergence of attenuated psychotic symptoms in early adulthood. In exploratory analyses, we examined whether cortisol and psychosocial stress measures interacted in predicting attenuated psychotic symptoms. METHODS: A sample of children (N = 109) enriched for psychosis risk factors were recruited at age..

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University of Melbourne Researchers