Hierarchical modelling of immunoglobulin coated bacteria in dogs with chronic enteropathy shows reduction in coating with disease remission but marked inter-individual and treatment-response variability
Lina Maria Martinez-Lopez, Alexis Perez-Gonzalez, Elizabeth Ann Washington, Andrew P Woodward, Alexandra Jazmin Roth-Schulze, Julien RS Dandrieux, Thurid Johnstone, Nathalee Prakash, Aaron Jex, Caroline Mansfield
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2021
Chronic enteropathies are a common problem in dogs, but many aspects of the pathogenesis remain unknown, making the therapeutic approach challenging in some cases. Environmental factors are intimately related to the development and perpetuation of gastrointestinal disease and the gut microbiome has been identified as a contributing factor. Previous studies have identified dysbiosis and reduced bacterial diversity in the gastrointestinal microbiota of dogs with chronic enteropathies. In this case-controlled study, we use flow cytometry and 16S rRNA sequencing to characterise bacteria highly coated with IgA or IgG in faecal samples from dogs with chronic enteropathy and evaluated their correla..View full abstract
This work was supported by the International and Postgraduate Research Scholarship (IPRS) from The Australian Government 2014 (LM). This work was funded by The Comparative and Gastroenterology Society/Waltham Grant 2016 (LM) [https://vetmed.tamu.edu/cgs/about/] and Early Career Researcher funding through the University of Melbourne 2018 (CM). The sponsors played no role in study design, data collection/analysis and were not involved in preparation of the publication or decision to publish.