The role of estrogens in osteosarcopenia: from biology to potential dual therapeutic effects
A Mandelli, E Tacconi, I Levinger, G Duque, A Hayes
CLIMACTERIC | TAYLOR & FRANCIS LTD | Published : 2021
Osteoporosis and sarcopenia are two conditions associated with aging and characterized by a simultaneous decline in bone and muscle mass, respectively. These conditions share common risk factors (genetic, endocrine, nutritional and lifestyle factors) and biological pathways that often co-exist in a syndrome known as osteosarcopenia. Among the endocrine causes, estrogens play a critical role, especially in women. Estrogens have been demonstrated to exert a positive effect on bone and muscle development and maintenance. For this reason, menopause is characterized by a loss in bone mineral density and skeletal muscle quality and quantity. To date, studies indicate a positive effect of hormonal ..View full abstract
This work was supported by the Australian Institute for Musculoskeletal Science (AIMSS) (Seed Grant).