Journal article

Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus

Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacos, Fatima Crispi, Gregory Duncombe, Martha Lappas, H David McIntyre, Gregory Rice, Carlos Salomon

JOURNAL OF TRANSLATIONAL MEDICINE | BMC | Published : 2021

Abstract

BACKGROUND: Gestational diabetes mellitus (GDM) is a serious public health issue affecting 9-15% of all pregnancies worldwide. Recently, it has been suggested that extracellular vesicles (EVs) play a role throughout gestation, including mediating a placental response to hyperglycaemia. Here, we investigated the EV-associated miRNA profile across gestation in GDM, assessed their utility in developing accurate, multivariate classification models, and determined the signaling pathways in skeletal muscle proteome associated with the changes in the EV miRNA profile. METHODS: Discovery: A retrospective, case-control study design was used to identify EV-associated miRNAs that vary across pregnancy ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Fondo Nacional de Desarrollo Cientifico y Tecnologico


Funding Acknowledgements

Lions Medical Research Foundation, Diabetes Australia, National Health and Medical Research Council (NHMRC; 1195451), Diabetes Australia and Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT 1170809). S.N. holds a Research Training Program Scholarship from the University of Queensland, funded by the Commonwealth Government of Australia.