Journal article

DIPG-46. NON-DIPG PATIENTS ENROLLED IN THE INTERNATIONAL DIPG REGISTRY: HISTOPATHOLOGIC EVALUATION OF CENTRAL NEURO-IMAGING REVIEW

Margot A Lazow, Christine Fuller, Adam Lane, Mariko D DeWire-Schottmiller, Pratiti Bandopadhayay, Ute Bartels, Eric Bouffet, Sylvia Cheng, Kenneth J Cohen, Tabitha M Cooney, Scott L Coven, Hetal Dholaria, Blanca Diez, Kathleen Dorris, Motasem El-Ayadi, Ayman El-Sheikh, Paul G Fisher, Mercedes Garcia Lombardi, Robert J Greiner, Stewart Goldman Show all

Neuro-oncology | Published : 2020

Abstract

Abstract INTRODUCTION The role of diagnostic biopsy in diffuse intrinsic pontine glioma (DIPG) remains in question. Distinguishing radiographically between DIPG and other pontine tumors with more favorable prognosis and different therapy is critically important. METHODS Cases submitted to the International DIPG registry with histopathologic data were analyzed. Central imaging review was performed by two neuro-radiologists; all cases with imaging features or histopathology suggestive of alternative diagnoses were re-reviewed. Imaging features suggestive of alternative diagnoses included non-pontine origin, <50% pontine involvement (without typical DIPG pattern on follow-up), focally exophytic..

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