Journal article

In silico predictions of protein interactions between Zika virus and human host

Joao Luiz de Lemos Padilha Pitta, Crhisllane Rafaele dos Santos Vasconcelos, Gabriel da Luz Wallau, Tulio de Lima Campos, Antonio Mauro Rezende

PEERJ | PEERJ INC | Published : 2021

Abstract

Background: The ZIKA virus (ZIKV) belongs to the Flaviviridae family, was first isolated in the 1940s, and remained underreported until its global threat in 2016, where drastic consequences were reported as Guillan-Barre syndrome and microcephaly in newborns. Understanding molecular interactions of ZIKV proteins during the host infection is important to develop treatments and prophylactic measures; however, large-scale experimental approaches normally used to detect protein-protein interaction (PPI) are onerous and labor-intensive. On the other hand, computational methods may overcome these challenges and guide traditional approaches on one or few protein molecules. The prediction of PPIs ca..

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University of Melbourne Researchers

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Funding Acknowledgements

This work was supported by Fundacao Oswaldo Cruz (FIOCRUZ). The computational platform used to apply the methodology described in this study was funded by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.