Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

TM Everson; M Vives-Usano; E Seyve; A Cardenas; M Lacasaña; JM Craig; C Lesseur; ER Baker; N Fernandez-Jimenez; B Heude; P Perron; B Gónzalez-Alzaga; J Halliday; MA Deyssenroth; MR Karagas; C Íñiguez; L Bouchard; P Carmona-Sáez; YJ Loke; K Hao; T Belmonte; MA Charles; J Martorell-Marugán; E Muggli; J Chen; MF Fernández; J Tost; A Gómez-Martín; SJ London; J Sunyer; CJ Marsit; J Lepeule; MF Hivert; M Bustamante

Journal article

Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

TM Everson, M Vives-Usano, E Seyve, A Cardenas, M Lacasaña, JM Craig, C Lesseur, ER Baker, N Fernandez-Jimenez, B Heude, P Perron, B Gónzalez-Alzaga, J Halliday, MA Deyssenroth, MR Karagas, C Íñiguez, L Bouchard, P Carmona-Sáez, YJ Loke, K Hao Show all

Nature Communications | Published : 2021

DOI: 10.1038/s41467-021-24558-y

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Abstract

Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tis..

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