Journal article

Elevated levels of circulating mitochondrial DNA predict early allograft dysfunction in patients following liver transplantation

Osamu Yoshino, Boris Ka Leong Wong, Daniel RA Cox, Eunice Lee, Graham Hepworth, Christopher Christophi, Robert Jones, Alexander Dobrovic, Vijayaragavan Muralidharan, Marcos Perini

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | WILEY | Published : 2021

Abstract

BACKGROUND AND AIM: The role of circulating mitochondrial DNA (cmtDNA) in transplantation remains to be elucidated. cmtDNA may be released into the circulation as a consequence of liver injury; yet recent work also suggests a causative role for cmtDNA leading to hepatocellular injury. We hypothesized that elevated cmtDNA would be associated with adverse events after liver transplantation (LT) and conducted an observational cohort study. METHODS: Twenty-one patients were enrolled prospectively prior to LT. RESULTS: Postoperative complications were observed in 47.6% (n = 10). Seven patients (33.3%) had early allograft dysfunction (EAD), and six patients (28.5%) experienced acute cellular rejec..

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