Journal article

Streptococcus salivarius K12 inhibits Candida albicans aggregation, biofilm formation and dimorphism

Munirah Mokhtar, Nurul Alia Risma Rismayuddin, Aini Syahida Mat Yassim, Hasna Ahmad, Ridhwan Abdul Wahab, Stuart Dashper, Mohd Hafiz Arzmi



Candida albicans causes candidiasis, particularly in immunocompromised patients. Streptococcus salivarius K12 (K12) is a probiotic isolated from a healthy oral cavity. The study aimed to determine the effect of K12 on C. albicans aggregation, biofilm formation and dimorphism. C. albicans ATCC MYA-4901, acquired immunodeficiency syndrome (AIDS) isolate (ALC2), and oral cancer isolate (ALC3) and K12 were used in the study. All C. albicans strains and K12 were grown in yeast peptone dextrose agar and brain heart infusion agar, respectively, prior to aggregation, biofilm and dimorphism assays. Auto-aggregation of C. albicans MYA-4901 and ALC2 was categorised as high, while the co-aggregation of ..

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University of Melbourne Researchers


Awarded by Ministry of Higher Education, Malaysia

Funding Acknowledgements

This study was funded by the Ministry of Higher Education, Malaysia, for the funding (FRGS/1/2018/SKK11/UIAM/03/1), the International Islamic University Malaysia (IIUM) for providing the laboratory and the Melbourne Dental School, The University of Melbourne for the microbial samples.