Journal article
Identification of the asymptomatic Plasmodium falciparum and Plasmodium vivax gametocyte reservoir under different transmission intensities
Cristian Koepfli, Wang Nguitragool, Anne Cristine Gomes de Almeida, Andrea Kuehn, Andreea Waltmann, Eline Kattenberg, Maria Ome-Kaius, Patricia Rarau, Thomas Obadia, James Kazura, Wuelton Monteiro, Andrew W Darcy, Lyndes Wini, Quique Bassat, Ingrid Felger, Jetsumon Sattabongkot, Leanne J Robinson, Marcus Lacerda, Ivo Mueller, Kamala Thriemer
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2021
Abstract
BACKGROUND: Understanding epidemiological variables affecting gametocyte carriage and density is essential to design interventions that most effectively reduce malaria human-to-mosquito transmission. METHODOLOGY/PRINCIPAL FINDINGS: Plasmodium falciparum and P. vivax parasites and gametocytes were quantified by qPCR and RT-qPCR assays using the same methodologies in 5 cross-sectional surveys involving 16,493 individuals in Brazil, Thailand, Papua New Guinea, and Solomon Islands. The proportion of infections with detectable gametocytes per survey ranged from 44-94% for P. falciparum and from 23-72% for P. vivax. Blood-stage parasite density was the most important predictor of the probability t..
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Awarded by TransEPI Consortium/Bill and Melinda Gates Foundation
Awarded by Australian National Health and Medical Research Council
Awarded by NIH
Awarded by Swiss National Science Foundation
Awarded by NHMRC
Funding Acknowledgements
This work was funded by the TransEPI Consortium/Bill and Melinda Gates Foundation (www.gatesfoundation.org, IM, OPP1034577), the Australian National Health and Medical Research Council (www.nhmrc.gov.au, IM, 1021544; 1092789), and NIH (www.nih.gov, JK, 1U19AI089686; IM, 1U19AI129392). This work was made possible through Victorian State & nbsp;Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. CK was supported by a fellowship from the Swiss National Science Foundation (#P2BSP3_151880). LJR was supported by an NHMRC Early Career Fellowship #1016443 (www.nhmrc.gov.au). IM is supported by a NHMRC Senior Research Fellowship (www.nhmrc.gov.au). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya (http://cerca.cat/en/suma/). CISM is supported by the Government of Mozambique and the Spanish Agency for International Development (AECID, www.aecid.es). The funders had no role in study design, sample or data collection, data analysis and interpretation, or decision to publish.