Journal article

Prevalence of Neutralising Antibodies to HCoV-NL63 in Healthy Adults in Australia

Sean A Lynch, Kanta Subbarao, Siddhartha Mahanty, Bridget E Barber, Eileen V Roulis, Lia van der Hoek, James S McCarthy, Kirsten M Spann

VIRUSES-BASEL | MDPI | Published : 2021


The COVID-19 pandemic has highlighted the importance of understanding the immune response to seasonal human coronavirus (HCoV) infections such as HCoV-NL63, how existing neutralising antibodies to HCoV may modulate responses to SARS-CoV-2 infection, and the utility of seasonal HCoV as human challenge models. Therefore, in this study we quantified HCoV-NL63 neutralising antibody titres in a healthy adult population using plasma from 100 blood donors in Australia. A microneutralisation assay was performed with plasma diluted from 1:10 to 1:160 and tested with the HCoV-NL63 Amsterdam-1 strain. Neutralising antibodies were detected in 71% of the plasma samples, with a median geometric mean titre..

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University of Melbourne Researchers