Journal article

Water-Borne Nanocoating for Rapid Inactivation of SARS-CoV-2 and Other Viruses

Valentin A Bobrin, Sung-Po Chen, Carlos Fitzgerald Grandes Reyes, Bing Sun, Chun Ki Ng, Youry Kim, Damian Purcell, Zhongfan Jia, Wenyi Gu, Jason W Armstrong, Julie McAuley, Michael J Monteiro

ACS NANO | AMER CHEMICAL SOC | Published : 2021

Abstract

The rise in coronavirus variants has resulted in surges of the disease across the globe. The mutations in the spike protein on the surface of the virion membrane not only allow for greater transmission but also raise concerns about vaccine effectiveness. Preventing the spread of SARS-CoV-2, its variants, and other viruses from person to person via airborne or surface transmission requires effective inactivation of the virus. Here, we report a water-borne spray-on coating for the complete inactivation of viral particles and degradation of their RNA. Our nanoworms efficiently bind and, through subsequent large nanoscale conformational changes, rupture the viral membrane and subsequently bind a..

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Grants

Funding Acknowledgements

The research was supported by The University of Queensland internal funds, Boeing Research and Technology Australia. The University of Melbourne acknowledges the support of Melbourne Health, through its Victorian Infectious Diseases Reference Laboratory at the Doherty Institute, in providing our laboratory with isolated SARS-CoV-2 material.