Journal article

Impact of preconception weight loss on fasting glucose and pregnancy outcomes in women with obesity: A randomized trial

Sarah AL Price, Priya Sumithran, Alison J Nankervis, Michael Permezel, Luke A Prendergast, Joseph Proietto

OBESITY | WILEY | Published : 2021


OBJECTIVE: This study examined the effectiveness of a nonsurgical, preconception weight loss intervention on pregnancy outcomes in women with obesity. METHODS: This was a two-arm, parallel-group randomized controlled trial. A total of 164 women with BMI 30 to 55 kg/m2 who were aged 18 to 38 years and planning pregnancy were randomized to a 12-week standard dietary intervention (SDI; n = 79) or a modified very low-energy diet (VLED; n = 85). Participants were observed for ≤48 weeks while trying for pregnancy and then during pregnancy. The primary outcome was maternal fasting plasma glucose at 26 to 28 weeks' gestation. Exploratory outcomes were individual and composite obesity-related adverse..

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