Journal article

PERMIT study: a global pooled analysis study of the effectiveness and tolerability of perampanel in routine clinical practice

Vicente Villanueva, Wendyl D'Souza, Hiroko Goji, Dong Wook Kim, Claudio Liguori, Rob McMurray, Imad Najm, Estevo Santamarina, Bernhard J Steinhoff, Pavel Vlasov, Tony Wu, Eugen Trinka

JOURNAL OF NEUROLOGY | SPRINGER HEIDELBERG | Published : 2021

Abstract

The PERaMpanel pooled analysIs of effecTiveness and tolerability (PERMIT) study was a pooled analysis of data from 44 real-world studies from 17 countries, in which people with epilepsy (PWE; focal and generalized) were treated with perampanel (PER). Retention and effectiveness were assessed after 3, 6, and 12 months, and at the last visit (last observation carried forward). Effectiveness assessments included 50% responder rate (≥ 50% reduction in seizure frequency from baseline) and seizure freedom rate (no seizures since at least the prior visit); in PWE with status epilepticus, response was defined as seizures under control. Safety and tolerability were assessed by evaluating adverse even..

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