Mechanism-based therapeutic targets of pemphigus vulgaris: A scoping review of pathogenic molecular pathways
Bavleen Kaur, Jenna Kerbrat, Jia Kho, Manreet Kaler, Stefanos Kanatsios, Nicola Cirillo
EXPERIMENTAL DERMATOLOGY | WILEY | Published : 2021
Pemphigus vulgaris (PV) is a potentially fatal autoimmune blistering disease characterised by cell-cell detachment or acantholysis. The mechanisms which follow antibody (Ab) binding and culminate in acantholytic changes and skin/mucosal blistering have not been fully clarified. Current treatment strategies are not specific to PV pathophysiology and although life-saving, harbour considerable side effects. We aimed to systematically assess the molecules amenable to targeted treatments that follow Ab binding and are associated with PV acantholysis. The resulting scoping review was conducted under PRISMA-ScR guidelines with clear inclusion and exclusion criteria and focused specifically on kinas..View full abstract
The authors wish to acknowledge the support of the Melbourne Dental School, The University of Melbourne.