Journal article

Mechanism-based therapeutic targets of pemphigus vulgaris: A scoping review of pathogenic molecular pathways

Bavleen Kaur, Jenna Kerbrat, Jia Kho, Manreet Kaler, Stefanos Kanatsios, Nicola Cirillo

EXPERIMENTAL DERMATOLOGY | WILEY | Published : 2021

Abstract

Pemphigus vulgaris (PV) is a potentially fatal autoimmune blistering disease characterised by cell-cell detachment or acantholysis. The mechanisms which follow antibody (Ab) binding and culminate in acantholytic changes and skin/mucosal blistering have not been fully clarified. Current treatment strategies are not specific to PV pathophysiology and although life-saving, harbour considerable side effects. We aimed to systematically assess the molecules amenable to targeted treatments that follow Ab binding and are associated with PV acantholysis. The resulting scoping review was conducted under PRISMA-ScR guidelines with clear inclusion and exclusion criteria and focused specifically on kinas..

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University of Melbourne Researchers