Journal article

The relation between cannabis use, dependence severity and white matter microstructure: A diffusion tensor imaging study

Janna Cousijn, Yara J Toenders, Laura S van Velzen, Anne Marije Kaag

ADDICTION BIOLOGY | WILEY | Published : 2021


Despite the significant societal and personal burden of cannabis use, the impact of long-term use and Cannabis Use Disorder (CUD) on white matter microstructure is still unclear. Previous studies show inconsistent findings, in part due to heterogeneity in methodology, variable severity of cannabis use, and potential confounding effects of other mental health issues and substance use. The goal of this diffusion tensor imaging (DTI) study was to compare whole-brain white matter microstructure between 39 near daily cannabis users and 28 controls closely matched on age, sex, alcohol use, cigarette use and mental health. Within the group of cannabis users, associations between white matter micros..

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Funding Acknowledgements

We thank Sabrina Okx, Fabio Melis, Anne Kramer and Scarlett Slagter for their help with data collection. This study was supported by a Replication Study grant from the Department of Psychology of the University of Amsterdam.