Journal article
Meal-time glycaemia in adults with type 1 diabetes using multiple daily injections vs insulin pump therapy following carbohydrate-counting education and bolus calculator provision
JC Lu, S Vogrin, SA McAuley, MH Lee, B Paldus, LA Bach, MG Burt, PM Clarke, ND Cohen, PG Colman, MI de Bock, D Jane Holmes-Walker, AJ Jenkins, J Kaye, AC Keech, K Kumareswaran, RJ MacIsaac, RW McCallum, K Roem, C Sims Show all
Diabetes Research and Clinical Practice | Published : 2021
Abstract
Aims: To compare meal-time glycaemia in adults with type 1 diabetes mellitus (T1D) managed with multiple daily injections (MDI) vs. insulin pump therapy (IPT), using self-monitoring blood glucose (SMBG), following diabetes education. Methods: Adults with T1D received carbohydrate-counting education and a bolus calculator: MDI (Roche Aviva Expert) and IPT (pump bolus calculator). All then wore 3-weeks of masked-CGM (Enlite, Medtronic). Meal-times were assessed by two approaches: 1) Set time-blocks (breakfast 06:00–10:00hrs; lunch 11:00–15:00hrs; dinner 17:00–21:00hrs) and 2) Bolus-calculator carbohydrate entries signalling meal commencement. Post-meal masked-CGM time-in-range (TIR) 3.9–10.0 m..
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Awarded by Abbott Laboratories
Funding Acknowledgements
This trial was funded by the JDRF Australian Type 1 Diabetes Clinical Research Network (3-SRA-2016-351-M-B), a special initiative of the Australian Research Council (ARC), and the National Health and Medical Research Council (NHMRC) of Australia (APP1099379). In-kind support was provided by Medtronic (HCL systems, masked CGM devices, and technical expertise with device issues), and Roche Diabetes Care (blood glucose meters for participants using MDI). We are grateful to the study volunteers for their participation. We acknowledge support by trial nurses, diabetes educators, and dietitians at the clinical sites; lead site trial nurse Sue-Anne Wyatt; DSMB members John Santamaria, Chris Cowell, Val Gebski, and Danny Liew; and central support at the University of Sydney by trial monitors, Helen Pater and Sarah Mulray, and database assistance by Dr Adrienne Kirby. SAM is supported by a JDRF Research Award (5-ECR-2017-371-A-N).