Journal article

Epigenetic programming underpins B-cell dysfunction in peanut and multi-food allergy

Samira Imran, Melanie R Neeland, Jennifer Koplin, Shyamali Dharmage, Mimi LK Tang, Susan Sawyer, Thanh Dang, Vicki McWilliam, Rachel Peters, Kirsten P Perrett, Boris Novakovic, Richard Saffery

CLINICAL & TRANSLATIONAL IMMUNOLOGY | WILEY | Published : 2021

Abstract

Objective: Rates of IgE-mediated food allergy (FA) have increased over the last few decades, and mounting evidence implicates disruption of epigenetic profiles in various immune cell types in FA development. Recent data implicate B-cell dysfunction in FA; however, few studies have examined epigenetic changes within these cells. Methods: We assessed epigenetic and transcriptomic profiles in purified B cells from adolescents with FA, comparing single-food-allergic (peanut only), multi-food-allergic (peanut and ≥1 other food) and non-allergic (control) individuals. Adolescents represent a phenotype of persistent and severe FA indicative of a common immune deviation. Results: We identified 144 d..

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Grants

Awarded by NHMRC (Australia)


Awarded by NHMRC (Australia) Investigator Grant


Funding Acknowledgements

This study was funded by an NHMRC (Australia) Project Grant (#1165073) to RS, MN and BN. BN is supported by an NHMRC (Australia) Investigator Grant (#1173314). MN is supported by a Melbourne Children's LifeCourse Fellowship. KP is supported by a Melbourne Children's Clinician Scientist Fellowship. We thank the students, parents and schools that participated in the SchoolNuts study.