Journal article

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

Jian Kang, Natalie Brajanovski, Keefe T Chan, Jiachen Xuan, Richard B Pearson, Elaine Sanij

SIGNAL TRANSDUCTION AND TARGETED THERAPY | SPRINGERNATURE | Published : 2021

Abstract

Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function. In addition to their canonical ribosomal functions, multiple RPs have extra-ribosomal functions including activation of p53-dependent or p53-independent pathways in response to stress, resulting in cell cycle arrest and apoptosis. Defects in ribosome biogenesis, translation, and the functions of individual RPs, including mutations in RPs have been linked to a diverse range of human congenital disorders termed ribosomopathies. Ribosomopathies are characte..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Cancer Council Victoria Project


Awarded by Senior Research NHMRC Fellowship


Awarded by Victorian Cancer Agency Mid-Career Research Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project grants #1053792 and #1162052) and Cancer Council Victoria Project Grant #1184873. R.B.P was supported by Senior Research NHMRC Fellowship #1058586. E.S. is supported by a Victorian Cancer Agency Mid-Career Research Fellowship (MCRF19007).