Journal article

Cerebrospinal fluid flow cytometry distinguishes psychosis spectrum disorders from differential diagnoses.

Saskia Räuber, Michael Heming, Jonathan Repple, Tillmann Ruland, Rebecca Kuelby, Andreas Schulte-Mecklenbeck, Catharina C Gross, Volker Arolt, Bernhard Baune, Tim Hahn, Udo Dannlowski, Sven G Meuth, Nico Melzer, Heinz Wiendl, Gerd Meyer Zu Hörste

Mol Psychiatry | Published : 2021

Abstract

Psychotic disorders are common and disabling mental conditions. The relative importance of immune-related mechanisms in psychotic disorders remains subject of debate. Here, we present a large-scale retrospective study of blood and cerebrospinal fluid (CSF) immune cell profiles of psychosis spectrum patients. We performed basic CSF analysis and multi-dimensional flow cytometry of CSF and blood cells from 59 patients with primary psychotic disorders (F20, F22, F23, and F25) in comparison to inflammatory (49 RRMS and 16 NMDARE patients) and non-inflammatory controls (52 IIH patients). We replicated the known expansion of monocytes in the blood of psychosis spectrum patients, that we identified ..

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University of Melbourne Researchers