Journal article

Dynamics of Epstein-Barr virus on post-transplant lymphoproliferative disorders after antithymocyte globulin-conditioned allogeneic hematopoietic cell transplant

Julian Lindsay, Jad Othman, Michelle K Yong, David Ritchie, Lynette Chee, KimHeng Tay, Shio Yen Tio, Ian Kerridge, Keith Fay, William Stevenson, Chris Arthur, Sharon C-A Chen, David CM Kong, Matthew Greenwood, Steven A Pergam, Catherine Liu, Monica A Slavin

TRANSPLANT INFECTIOUS DISEASE | WILEY | Published : 2021

Abstract

BACKGROUND: The use of antithymocyte globulin (ATG) in allogeneic hematopoietic cell transplant (HCT) is associated with an increased risk of Epstein-Barr virus (EBV) reactivation and post-transplant lymphoproliferative disorders (PTLD). The dynamics and outcomes of EBV-DNAemia are not well described in this population. METHODS: We retrospectively assessed the kinetics of EBV-DNAemia after ATG conditioning of HCT recipients. Receiver operating characteristic (ROC) curves were used to assess EBV-DNAemia to predict EBV-PTLD in this group. RESULTS: A total of 174/405 (43%) consecutive HCT recipients from two centers met inclusion criteria of ATG conditioned, non-B-cell lymphoma patients. Of the..

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