Journal article
MPS 18-04 FASUDIL PREVENTS CORONARY MICROVASCULAR ENDOTHELIAL DYSFUNCTION AND CARDIAC CONTRACTILE DYSFUNCTION IN A RAT MODEL OF HYPERTENSIVE DIABETES MORE THAN LOSARTAN
James Pearson, Hirotsugu Tsuchimochi, Tadakatsu Inagaki, Cheng-Kun Du, Dong-Yun Zhang, Daryl Schwenke, Amanda Edgley, Keiji Umetani, Naoto Yagi, Mikiyasu Shirai
Journal of Hypertension | Ovid Technologies (Wolters Kluwer Health) | Published : 2016
Abstract
Objective: Diabetes, hypertension and obesity are risk factors for the development of heart failure. Rho kinase (ROCK) appears to drive the coronary and contractile dysfunction in early diabetes and in hypertension. We hypothesised that ROCK activation plays a critical role in diabetic heart failure. Design and Method: Using synchrotron radiation microangiography and in vivo small-angle X-ray scattering (SAXS) approaches, we investigated the effect of combined hypertension and insulin resistance on coronary microvessel and cardiac function in lean male rats. Young adult Goto-Kakizaki (GK) rats (n = 9 /group) were maintained on a high salt (6%NaCl) diet for 8 weeks with normal drinking water ..
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