Journal article

Enteric neuroimmune interactions coordinate intestinal responses in health and disease

Haozhe Wang, Jaime PP Foong, Nicola L Harris, Joel C Bornstein



The enteric nervous system (ENS) of the gastrointestinal (GI) tract interacts with the local immune system bidirectionally. Recent publications have demonstrated that such interactions can maintain normal GI functions during homeostasis and contribute to pathological symptoms during infection and inflammation. Infection can also induce long-term changes of the ENS resulting in the development of post-infectious GI disturbances. In this review, we discuss how the ENS can regulate and be regulated by immune responses and how such interactions control whole tissue physiology. We also address the requirements for the proper regeneration of the ENS and restoration of GI function following the res..

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Funding Acknowledgements

We are grateful to Dr. Lakshanie C. Wickramasinghe for careful proofreading and providing critical suggestions to the paper. N.L.H. is supported by a National Health and Medical Research Council (NHMRC) of Australia SRF-B fellowship.