Journal article

10.2 REDOX DYSREGULATION, OLIGODENDROCYTES AND WHITE MATTER ALTERATIONS IN SCHIZOPHRENIA

Paul Klauser, Philipp S Baumann, Margot Fournier, Lijing Xin, Alessandra Griffa, Martine Cleusix, Raoul Jenni, Michel Cuenod, Patric Hagmann, Philippe Conus, Kim Q Do

Schizophrenia bulletin | Published : 2018

Abstract

Abstract Background Widespread (Klauser et al., 2016) and progressive (Cropley et al., 2017) cerebral anomalies of white matter diffusion properties (i.e. fractional anisotropy, FA) have been observed in the Australian Schizophrenia Research Bank (ASRB), one of the largest samples of patients with schizophrenia. From a topological perspective, widespread alterations of white matter tend to concentrate into hub regions that interconnect brain areas over long-distances in a so-called “rich-club” (van den Heuvel et al., 2013; Klauser et al., 2016) in which the metabolic demand is high and thus are most likely to suffer from oxidative stress. Evidence from human and animal models suggests that r..

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