Journal article
16.2 CHILDHOOD TRAUMA ENGAGES OXIDATIVE STRESS, HIPPOCAMPUS ALTERATIONS, AND POORER CLINICAL OUTCOME IN EARLY PSYCHOSIS PATIENTS
Luis Alameda, Margot Fournier, Ines Khadimallah, Philippe S Baumann, Martine Cleusix, Alessandra Griffa, Paul Klauser, Raoul Jenni, Michel Cuenod, Patric Hagmann, Philippe Conus, Kim Do
Schizophrenia bulletin | Published : 2018
Abstract
Abstract Background Exposure to childhood trauma (CT) is a global major public-health and social-welfare problem worldwide. CT increases the vulnerability to major psychiatric conditions including psychosis and is associated with poorer clinical outcome. CT affects the development of brain structures such as hippocampus, possibly through oxidative stress and neuroinflammation, two mechanisms linked to psychosis. We therefore hypothesized that there is an interplay between oxidative stress and CT in psychosis patients. We thus explored in early psychosis patients the relationships between CT and i) hippocampal volume, ii) antioxidant systems; and iii) clinical and cognitive outcomes. Methods ..
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