Physical activity and sedentary behaviour over adulthood in relation to all-cause and cause-specific mortality: A systematic review of analytic strategies and study findings

Abstract

Background: Questions remain about the effect on mortality of physical activity and sedentary behaviour over time. We summarized the evidence from studies that assessed exposure from multiple time points and critiqued the analytic approaches used. Methods: A search was performed on MEDLINE, Embase, Emcare, Scopus and Web of Science up to January 2021 for studies of repeatedly assessed physical activity or sedentary behaviour in relation to all-cause or cause-specific mortality. Relative risks from individual studies were extracted. Each study was assessed for risk of bias from multiple domains. Results: We identified 64 eligible studies (57 on physical activity, 6 on sedentary behaviour, 1 o..