The immunological link between neonatal lung and eye disease
Lakshanie C Wickramasinghe, Peter van Wijngaarden, Evelyn Tsantikos, Margaret L Hibbs
CLINICAL & TRANSLATIONAL IMMUNOLOGY | WILEY | Published : 2021
Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are two neonatal diseases of major clinical importance, arising in large part as a consequence of supplemental oxygen therapy used to promote the survival of preterm infants. The presence of coincident inflammation in the lungs and eyes of neonates receiving oxygen therapy indicates that a dysregulated immune response serves as a potential common pathogenic factor for both diseases. This review examines the current state of knowledge of immunological dysregulation in BPD and ROP, identifying similarities in the cellular subsets and inflammatory cytokines that are found in the alveoli and retina during the active phase of t..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by grant funding from the National Health and Medical Research Council of Australia (APP1141208 to MLH and ET). LCW was supported by a scholarship from the Australian Government administered by Monash University. The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government.