Journal article

Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis

Marta Rapado-Castro, Mara Villar-Arenzana, Joost Janssen, David Fraguas, Igor Bombin, Josefina Castro-Fornieles, Maria Mayoral, Ana Gonzalez-Pinto, Elena de la Serna, Mara Parellada, Dolores Moreno, Beatriz Paya, Montserrat Graell, Inmaculada Baeza, Christos Pantelis, Celso Arango

JOURNAL OF CLINICAL MEDICINE | MDPI | Published : 2021

Abstract

Cognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in early onset psychosis (EOP). Studies examining longitudinal brain changes and cognitive performance in psychosis lend support for an altered development of high-order cognitive functions, which parallels progressive gray matter (GM) loss over time, particularly in fronto-parietal brain regions. We aimed to assess this relationship in a subsample of 33 adolescents with first-episode EOP and 47 matched controls over 2 years. Backwards stepwise regression analyses were conducted to determine the association and predictive value of longitudinal brain changes over cog..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III, Redes Tematicas-ISCIII


Awarded by RETICS (REM-TAP Network)


Awarded by Spanish Ministry of Science, Innovation and Universities


Awarded by NARSAD from the Brain and Behavior Research Foundation


Awarded by Instituto de Salud Carlos III


Awarded by ISCIII


Awarded by University of the Basque Country


Awarded by Basque Government


Awarded by European Regional Development Fund (ERDF/FEDER)


Awarded by National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship


Awarded by NHMRC L3 Investigator Grant


Awarded by Madrid Regional Government


Awarded by European Union


Funding Acknowledgements

This work was supported by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III, Redes Tematicas-ISCIII G03-032; RETICS (REM-TAP Network) RD06/0011; CIBERSAM. MR-C is a Ramon y Cajal Research Fellow (RYC-2017-23144), Spanish Ministry of Science, Innovation and Universities and was supported by a NARSAD independent investigator grant (No. 24628) from the Brain and Behavior Research Foundation. JJ has received grant/research support from European Union Funds, Instituto de Salud Carlos III Spanish Ministry of Economy and Competitiveness, and Ramon y Cajal Research Fellowship program, Spanish Ministry of Science, Innovation and Universities DF was partially supported by the Spanish Ministry of Science and Innovation. Instituto de Salud Carlos III (PI14/00397, PI17/00481, PI20/00216), co-financed by ERDF Funds from the European Commission, "A way of making Europe". IB was supported by ISCIII (INT19/00021). AG-P was supported by the University of the Basque Country 321218ELCY IT1232-19, and the Basque Government 2017111104, the Carlos III Healthcare Institute, the Spanish Ministry of Science, Innovation and Universities, the European Regional Development Fund (ERDF/FEDER) (PI18/01055). CP was supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1105825), an NHMRC L3 Investigator Grant (1196508) MR-C, JJ, MM, MP, DM and CA were partially supported by the Spanish Ministry of Science and Innovation. Instituto de Salud Carlos III, (PI18/00753), co-financed by ERDF Funds from the European Commission, "A way of making Europe", CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds. European Union Seventh Framework Program under grant agreements FP7-HEALTH-2009-2.2.1-2-241909 (Project EU-GEI), FP7-HEALTH-2009-2.2.1-3-242114 (Project OPTiMISE), FP7- HEALTH-2013-2.2.1-2-603196 (Project PSYSCAN) and FP7- HEALTH-2013- 2.2.1-2-602478 (Project METSY); and European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking (grant agreement No. 115916, Project PRISM, and grant agreement No. 777394, Project AIMS-2-TRIALS), Fundacion Familia Alonso and Fundacion Alicia Koplowitz.