Journal article

The causal effect of being born extremely preterm or extremely low birthweight on neurodevelopment and social-emotional development at 2 years

Joy E Olsen, Katherine J Lee, Alicia J Spittle, Peter J Anderson, Lex W Doyle, Jeanie LY Cheong

ACTA PAEDIATRICA | WILEY | Published : 2021

Abstract

AIM: To assess the causal effect of being born extremely preterm (EP; <28 weeks' gestation) or extremely low birthweight (ELBW; <1000 g), compared with being born at term, on neurodevelopment and social-emotional development at 2 years' corrected age. METHODS: Prospective geographical cohort study of children born EP/ELBW over 12 months in 2016 from Victoria, Australia, and term-born controls. Children were assessed at 2 years' corrected age with the Bayley Scales of Infant and Toddler Development-3rd edition and the Infant-Toddler Social and Emotional Assessment. Delay was defined as <-1 standard deviation relative to the mean of controls. The estimand of interest was the mean difference/od..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Medical Research Future Fund of Australia


Funding Acknowledgements

The National Health and Medical Research Council of Australia (Centre of. Clinical Research Excellence #546519; Centre of Research Excellence #1060733 #1153176; Project Grant #108702; Career Development Fellowship #1108714 to. AJS, #1127984 to KJL; Senior Research Fellowship #1081288 to PJA and Investigator Grant #1176077), the Medical Research Future Fund of Australia (Career Development Fellowship #1141354 to JLYC) and the Victorian Government's Operational Infrastructure Support Program