Trans-chalcone plus baicalein synergistically reduce intracellular amyloid beta (Aβ42) and protect from Aβ42 induced oxidative damage in yeast models of Alzheimer’s disease

Abstract

Finding an effective therapeutic to prevent or cure AD has been difficult due to the com-plexity of the brain and limited experimental models. This study utilized unmodified and genetically modified Saccharomyces cerevisiae as model organisms to find potential natural bioactive compounds capable of reducing intracellular amyloid beta 42 (Aβ42) and associated oxidative damage. Eleven natural bioactive compounds including mangiferin, quercetin, rutin, resveratrol, epigallo-catechin gallate (EGCG), urolithin A, oleuropein, rosmarinic acid, salvianolic acid B, baicalein and trans-chalcone were screened for their ability to reduce intracellular green fluorescent protein tagged Aβ42 (GFP-Aβ42) lev..