Journal article

Is cardiorespiratory disease associated with increased susceptibility of SARS-CoV-2 in children?

Cassidy Du Berry, Thomas Saunders, Alissa McMinn, Shidan Tosif, Shivanthan Shanthikumar, Moya Vandeleur, Joanne Harrison, David Burgner, Sarath Ranganathan, Nigel Crawford, Danielle Wurzel



BACKGROUND: There are limited data in pediatric populations evaluating whether chronic cardiorespiratory conditions are associated with increased risk of coronavirus disease 2019 (COVID-19). We aimed to compare the rates of chronic cardiac and respiratory disease in children testing positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2[+]) compared with those testing negative (SARS-CoV-2[-]) at our institution. METHOD: Prospective cohort with nested case-control study of all children tested by polymerase chain reaction (PCR) for SARS-CoV-2 by nasopharyngeal/oropharyngeal sampling between March and October 2020. Children were identified prospectively via laboratory notification..

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Funding Acknowledgements

The Influenza Complications Alert Network Surveillance System; Centers of Excellence in Influenza Research and Surveillance - Cross-Center Southern Hemisphere Project; Paediatric Active Enhanced Disease Surveillance and Sentinel Travelers and Research Preparedness Platform for Emerging Infectious Disease; Murdoch Children's Research Institute