Journal article

Midline Shift Greater than 3 mm Independently Predicts Outcome After Ischemic Stroke

Morgan E McKeown, Ayush Prasad, Jessica Kobsa, Ilayda Top, Samuel B Snider, Chelsea Kidwell, Bruce CV Campbell, Stephen M Davis, Geoffrey A Donnan, Michael Lev, Kevin N Sheth, Nils Petersen, W Taylor Kimberly, Matthew B Bevers



BACKGROUND: Cerebral edema is associated with worse outcome after acute stroke; however, the minimum clinically relevant threshold remains unknown. This study aimed to identify the minimal degree of midline shift (MLS) that predicts outcome in a cohort encompassing a broad range of patients with acute stroke. METHODS: Patient-level data from six acute stroke clinical trials were combined with endovascular thrombectomy registries from two academic referral centers, generating a combined cohort of 1977 patients. MLS was extracted from the original trial data or measured on computed tomography or magnetic resonance imaging that was obtained a median of 47.0 h (interquartile range 27.0-75.1 h) a..

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Awarded by NIH

Awarded by AAN CRTS

Awarded by AHA

Funding Acknowledgements

This work was funded by NIH K23NS112474 (MBB), AAN CRTS AI180000000062 (MBB), NIH R01 NS099209 (WTK), and AHA 20SRG35540018 (WTK).