Journal article

Utilising surface-level data to explore surface, tooth, individual and family influence on the aetiology of hypomineralised second primary molars

MJ Silva, Y Zheng, S Zaloumis, DP Burgner, JM Craig, DJ Manton, NM Kilpatrick, KJ Scurrah

JOURNAL OF DENTISTRY | ELSEVIER SCI LTD | Published : 2021

Abstract

OBJECTIVES: Hypomineralised second primary molars (HSPM) are common developmental enamel defects. The aims of this study were to use surface-level data to explore the clustering of HSPM at four levels (family, child, tooth, surface). METHODS: This study of 172 twin pairs was nested within the Peri/postnatal Epigenetic Twin Study. HSPM was measured by standardised oral examinations at age 6 years. Multilevel logistic regression models were fitted to assess the correlation structure of surface level data and variation in HSPM. The associations between surface level risk factors and HSPM were then explored using the multilevel logistic regression model using the best fitting correlation structu..

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Grants

Awarded by National Institute of Dental and Craniofacial Research of the National Institutes of Health


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Bonnie Babes Foundation


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC


Funding Acknowledgements

The research in this publication was supported by the National Institute of Dental and Craniofacial Research of the National Institutes of Health under Award Number R01DE019665. The Peri/Postnatal Epigenetic Twins Study (PETS) was supported by grants from the National Health and Medical Research Council (NHMRC) (GTN437015 and GTN607358) , the Bonnie Babes Foundation (grant number BBF20704) , the Financial Markets Foundation for Children (grant number 032-2007) , the Victorian Government's Operational Infrastructure Support Program, the Australian and New Zealand Society for Paediatric Dentistry Victorian Branch and The University of Melbourne Paediatric Dentistry Fund. MS is supported by a Melbourne Children's Clinician-Scientist Fellowship. KS is supported by a Centre of Research Excellence Grant in Twin Research and a NHMRC project grant (GTN1084197) . DB is supported by an NHMRC Investigator Grant (GTN1175744) .