Functional microRNA targetome undergoes degeneration-induced shift in the retina
Joshua A Chu-Tan, Adrian V Cioanca, Zhi-Ping Feng, Yvette Wooff, Ulrike Schumann, Riemke Aggio-Bruce, Hardip Patel, Matt Rutar, Katherine Hannan, Konstantin Panov, Jan Provis, Riccardo Natoli
MOLECULAR NEURODEGENERATION | BMC | Published : 2021
BACKGROUND: MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through their association with argonaute 2 (AGO2) - a key member of the RNA Induced Silencing Complex (RISC). Identifying the retinal miRNA/mRNA interactions in health and disease will provide important insight into the key pathways miRNA regulate in disease pathogenesis and may lead to potential therapeutic targets to mediate retinal degeneration. METHODS: To identify the active miRnome targetome interactions in the healthy and degenerating retina, AGO2 HITS-CLIP was performed using a ..View full abstract
Awarded by National Health and Medical Research Council of Australia, Retina Australia
This work would not have been possible without the support of the National Health and Medical Research Council of Australia (NHMRC: 1127705, NHMRC: 202239), Retina Australia, The Gordon and Gretel Bootes Foundation and The ANU Translational Fellowship.