Journal article

High expression of CD38 and MHC class II on CD8( ) T cells during severe influenza disease reflects bystander activation and trogocytosis

Xiaoxiao Jia, Brendon Y Chua, Liyen Loh, Marios Koutsakos, Lukasz Kedzierski, Moshe Olshansky, William R Heath, So Young Chang, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska



Objectives: Although co-expression of CD38 and HLA-DR reflects T-cell activation during viral infections, high and prolonged CD38+HLA-DR+ expression is associated with severe disease. To date, the mechanism underpinning expression of CD38+HLA-DR+ is poorly understood. Methods: We used mouse models of influenza A/H9N2, A/H7N9 and A/H3N2 infection to investigate mechanisms underpinning CD38+MHC-II+ phenotype on CD8+ T cells. To further understand MHC-II trogocytosis on murine CD8+ T cells as well as the significance behind the scenario, we used adoptively transferred transgenic OT-I CD8+ T cells and A/H3N2-SIINKEKL infection. Results: Analysis of influenza-specific immunodominant DbNP366 +CD8+..

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Awarded by Australian National Health and Medical Research Council (NHMRC) Program Grant

Awarded by NHMRC Investigator Grant

Funding Acknowledgements

The authors thank Professor SJ Turner for insightful discussions. This workwas supported by the Australian National Health and Medical Research Council (NHMRC) Program Grant (#1071916) and NHMRC Investigator Grant (#1173871) to KK. XJ was a recipient of China Scholarship Council-UoM Joint Scholarship. SYC was a recipient of Melbourne Research Scholarship from University of Melbourne.