Genomic Diversity and Antimicrobial Resistance of Haemophilus Colonizing the Airways of Young Children with Cystic Fibrosis
Stephen C Watts, Louise M Judd, Rosemary Carzino, Sarath Ranganathan, Kathryn E Holt
MSYSTEMS | AMER SOC MICROBIOLOGY | Published : 2021
Respiratory infection during childhood is a key risk factor in early cystic fibrosis (CF) lung disease progression. Haemophilus influenzae and Haemophilus parainfluenzae are routinely isolated from the lungs of children with CF; however, little is known about the frequency and characteristics of Haemophilus colonization in this context. Here, we describe the detection, antimicrobial resistance (AMR), and genome sequencing of H. influenzae and H. parainfluenzae isolated from airway samples of 147 participants aged ≤12 years enrolled in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF) program, Melbourne, Australia. The frequency of colonization per visit was 4...View full abstract
Awarded by Bill & Melinda Gates Foundation, Seattle
This work was supported by the Bill & Melinda Gates Foundation, Seattle (K.E.H. [OPP1175797] ) , and the Australian Government Research Training Program (S.C.W.) . K.E.H. was supported by a Senior Medical Research Fellowship from the Viertel Foundation of Victoria.