Journal article

NF-kappa B and Pancreatic Cancer; Chapter and Verse

John Silke, Lorraine Ann O'Reilly

CANCERS | MDPI | Published : 2021

Abstract

Pancreatic Ductal Adenocarcinoma (PDAC) is one of the world's most lethal cancers. An increase in occurrence, coupled with, presently limited treatment options, necessitates the pursuit of new therapeutic approaches. Many human cancers, including PDAC are initiated by unresolved inflammation. The transcription factor NF-κB coordinates many signals that drive cellular activation and proliferation during immunity but also those involved in inflammation and autophagy which may instigate tumorigenesis. It is not surprising therefore, that activation of canonical and non-canonical NF-κB pathways is increasingly recognized as an important driver of pancreatic injury, progression to tumorigenesis a..

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University of Melbourne Researchers

Grants

Awarded by Cancer Council Victoria


Awarded by Cancer Council New SouthWales


Awarded by NHMRC


Funding Acknowledgements

This review was in part funded by a Cancer Council Victoria Grant-in-Aid project, grant number 1161400 (to L. O'Reilly) and a Cancer Council New SouthWales project grant number G20-13 (to L. O'Reilly) and NHMRC fellowships to JS NHMRC 1107149 & 1195038.