NF-kappa B and Pancreatic Cancer; Chapter and Verse
John Silke, Lorraine Ann O'Reilly
CANCERS | MDPI | Published : 2021
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the world's most lethal cancers. An increase in occurrence, coupled with, presently limited treatment options, necessitates the pursuit of new therapeutic approaches. Many human cancers, including PDAC are initiated by unresolved inflammation. The transcription factor NF-κB coordinates many signals that drive cellular activation and proliferation during immunity but also those involved in inflammation and autophagy which may instigate tumorigenesis. It is not surprising therefore, that activation of canonical and non-canonical NF-κB pathways is increasingly recognized as an important driver of pancreatic injury, progression to tumorigenesis a..View full abstract
Awarded by Cancer Council Victoria
Awarded by Cancer Council New SouthWales
Awarded by NHMRC
This review was in part funded by a Cancer Council Victoria Grant-in-Aid project, grant number 1161400 (to L. O'Reilly) and a Cancer Council New SouthWales project grant number G20-13 (to L. O'Reilly) and NHMRC fellowships to JS NHMRC 1107149 & 1195038.