Validation of a Semiautomatic Image Analysis Software for the Quantification of Musculoskeletal Tissues
Mahdi Imani, Ebrahim Bani Hassan, Sara Vogrin, Aaron Samuel Tze Nor Ch'Ng, Nancy E Lane, Jane A Cauley, Gustavo Duque
CALCIFIED TISSUE INTERNATIONAL | SPRINGER | Published : 2021
Accurate quantification of bone, muscle, and their components is still an unmet need in the musculoskeletal field. Current methods to quantify tissue volumes in 3D images are expensive, labor-intensive, and time-consuming; thus, a reliable, valid, and quick application is highly needed. Tissue Compass is a standalone software for semiautomatic segmentation and automatic quantification of musculoskeletal organs. To validate the software, cross-sectional micro-CT scans images of rat femur (n = 19), and CT images of hip and abdomen (n = 100) from the Osteoporotic Fractures in Men (MrOS) Study were used to quantify bone, hematopoietic marrow (HBM), and marrow adipose tissue (MAT) using commercia..View full abstract
This study was funded via a Seed Grant from the Australian Institute for Musculoskeletal Science (AIMSS). EB was supported by the Australian Medical Research Frontiers Fund fellowship (MRFF; Melbourne Academic Centre for Health: MACH-RART scheme, 2019).