Journal article
Optimally Hierarchical Nanostructured Hydroxyapatite Coatings for Superior Prosthesis Biointegration
N Nasiri, S Mukherjee, A Panneerselvan, DR Nisbet, A Tricoli
ACS Applied Materials and Interfaces | Published : 2018
Abstract
Bone osteogenesis is a complex phenomenon dependent on numerous microenvironmental cues, with their synchrony regulating cellular functions, such as mechanical signaling, survival, proliferation, and differentiation, as well as controlled regional specification of skeletal progenitor cell fate. Therefore, obtaining a mechanistic understanding of cellular response to a microenvironment is now coming into intense focus, which will facilitate the design of programmable biomaterials for regenerative medicine. State-of-the-art nanomaterial synthesis and self-assembly processes yield complex structures that mimic surface properties, composition, and partially the morphology of the extracellular ma..
View full abstractGrants
Awarded by Australian National Fabrication Facility
Funding Acknowledgements
The authors would like to acknowledge V. Gautam and Z. Stachurski for critically reading the manuscript. A.T. gratefully acknowledges the financial support from the Australian Research Council Discovery Project (DP150101939) and Discovery Early Career Award (DE160100569). D.R.N. was supported by an NHMRC Career Development Fellowship (GNT1050684) and subsequently an NHMRC Research Leadership Fellowship (GNT1135657). Access to the facilities of the Centre for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) and the ACT node of the Australian National Fabrication Facility is gratefully acknowledged.