Scaffolds Formed via the Non-Equilibrium Supramolecular Assembly of the Synergistic ECM Peptides RGD and PHSRN Demonstrate Improved Cell Attachment in 3D.
San-Seint S Aye, Rui Li, Mitchell Boyd-Moss, Benjamin Long, Sivapriya Pavuluri, Kiara Bruggeman, Yi Wang, Colin R Barrow, David R Nisbet, Richard J Williams
Polymers (Basel) | Published : 2018
Self-assembling peptides (SAPs) are a relatively new class of low molecular weight gelators which immobilize their solvent through the spontaneous formation of (fibrillar) nanoarchitectures. As peptides are derived from proteins, these hydrogels are ideal for use as biocompatible scaffolds for regenerative medicine. Importantly, due to the propensity of peptide sequences to act as signals in nature, they are easily functionalized to be cell instructive via the inclusion of bioactive epitopes. In nature, the fibronectin peptide sequence, arginine-glycine-aspartic acid (RGD) synergistically promotes the integrin α₅β₁ mediated cell adhesion with another epitope, proline-histidine-serine-arginin..View full abstract