Controlling integrin-based adhesion to a degradable electrospun fibre scaffold via SI-ATRP.
Andrew E Rodda, Francesca Ercole, Veronica Glattauer, David R Nisbet, Kevin E Healy, Andrew P Dove, Laurence Meagher, John S Forsythe
J Mater Chem B | Published : 2016
While polycaprolactone (PCL) and similar polyesters are commonly used as degradable scaffold materials in tissue engineering and related applications, non-specific adsorption of environmental proteins typically precludes any control over the signalling pathways that are activated during cell adhesion to these materials. Here we describe the preparation of PCL-based fibres that facilitate cell adhesion through well-defined pathways while preventing adhesion via adsorbed proteins. Surface-initiated atom transfer radical polymerisation (SI-ATRP) was used to graft a protein-resistant polymer brush coating from the surface of fibres, which had been electrospun from a brominated PCL macroinitiator..View full abstract