Journal article
Ultra-Porous Nanoparticle Networks: A Biomimetic Coating Morphology for Enhanced Cellular Response and Infiltration
N Nasiri, A Ceramidas, S Mukherjee, A Panneerselvan, DR Nisbet, A Tricoli
Scientific Reports | Published : 2016
DOI: 10.1038/srep24305
Abstract
Orthopedic treatments are amongst the most common cause of surgery and are responsible for a large share of global healthcare expenditures. Engineering materials that can hasten bone integration will improve the quality of life of millions of patients per year and reduce associated medical costs. Here, we present a novel hierarchical biomimetic coating that mimics the inorganic constituent of mammalian bones with the aim of improving osseointegration of metallic implants. We exploit the thermally-driven self-organization of metastable core-shell nanoparticles during their aerosol self-assembly to rapidly fabricate robust, ultra-porous nanoparticle networks (UNN) of crystalline hydroxyapatite..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors would like to acknowledge K. Bruggeman, Z. Stachurski and F. Brink for critically reading the manuscript. Financial support from the Australian Research Council Discovery Project (150101939) and Discovery Early Career Award (160100569) is gratefully acknowledged by A. Tricoli. D. Nisbet was supported by an NHMRC Career Development Fellowship (APP1050684). Access to the facilities of the Centre for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) is gratefully acknowledged. The FTIR analyses were conducted in the Research School of Chemistry of the Australian National University.