Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells.
Rui Li, Sivapriya Pavuluri, Kiara Bruggeman, Benjamin M Long, Andrew J Parnell, Anne Martel, Steven R Parnell, Frederick M Pfeffer, Andrew JC Dennison, Kevin R Nicholas, Colin J Barrow, David R Nisbet, Richard J Williams
Nanomedicine | Published : 2016
The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications is the nanostructured scaffolds formed by epitope presenting minimalist self-assembled peptides; these are bioactive on a cellular length scale, while presenting as an easily handled hydrogel. Here, we show that the assembly process can distribute an anti-inflammatory polysaccharide, fucoidan, localized to the nanofibers within the scaffold to create a biomateri..View full abstract