In vitro response to functionalized self-assembled peptide scaffolds for three-dimensional cell culture.
Vengama N Modepalli, Alexandra L Rodriguez, Rui Li, Sivapriya Pavuluri, Kevin R Nicholas, Colin J Barrow, David R Nisbet, Richard J Williams
Biopolymers | Published : 2014
Nanomaterials are rich in potential, particularly for the formation of scaffolds that mimic the landscape of the host environment of the cell. This niche arises from the spatial organization of a series of biochemical and biomechanical signals. Self-assembling peptides have emerged as an important tool in the development of functional (bio-)nanomaterials; these simple, easily synthesized subunits form structures which present the properties of these larger, more complex systems. Scaffolds based upon these nanofibrous matrices are promising materials for regenerative medicine as part of a new methodology in scaffold design where a "bottom-up" approach is used in order to simulate the native c..View full abstract