Journal article

Anti-inflammatory and neuroprotective properties of the corticosteroid fludrocortisone in retinal degeneration

Tanja Racic, Andrew Chang, Nilisha Fernando, Alice Brandli, Riccardo Natoli, Philip Penfold, Jan M Provis, Matt Rutar

EXPERIMENTAL EYE RESEARCH | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2021

Abstract

The pathogenesis of outer retinal degenerations has been linked to the elevation of cytokines that orchestrate pro-inflammatory responses within the retinal milieu, and which are thought to play a role in diseases such as geographic atrophy (GA), an advanced form of AMD. Here we sought investigate the anti-inflammatory and mechanistic properties of fludrocortisone (FA), as well as triamcinolone acetonide (TA), on Müller cell-mediated cytokine expression in response to inflammatory challenge. In addition, we investigated the neuroprotective efficacy of FA and TA in a photo-oxidative damage (PD), a model of outer retinal degeneration. Expression of CCL2, IL-6, and IL-8 with respect to FA and T..

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Grants

Awarded by National and Health and Medical Research Council of Australia (NHMRC)


Funding Acknowledgements

This investigation was supported by grants from the National and Health and Medical Research Council of Australia (NHMRC, GNT1165599), and the Gordon and Gretel Bootes Foundation. Neither of these organizations had any role in the design or undertaking of this research.