Anti-inflammatory and neuroprotective properties of the corticosteroid fludrocortisone in retinal degeneration.
Tanja Racic, Andrew Chang, Nilisha Fernando, Alice Brandli, Riccardo Natoli, Philip Penfold, Jan M Provis, Matt Rutar
Exp Eye Res | Published : 2021
The pathogenesis of outer retinal degenerations has been linked to the elevation of cytokines that orchestrate pro-inflammatory responses within the retinal milieu, and which are thought to play a role in diseases such as geographic atrophy (GA), an advanced form of AMD. Here we sought investigate the anti-inflammatory and mechanistic properties of fludrocortisone (FA), as well as triamcinolone acetonide (TA), on Müller cell-mediated cytokine expression in response to inflammatory challenge. In addition, we investigated the neuroprotective efficacy of FA and TA in a photo-oxidative damage (PD), a model of outer retinal degeneration. Expression of CCL2, IL-6, and IL-8 with respect to FA and T..View full abstract