Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness

R Sanfelici; A Ruef; LA Antonucci; N Penzel; A Sotiras; MS Dong; M Urquijo-Castro; J Wenzel; L Kambeitz-Ilankovic; MD Hettwer; S Ruhrmann; K Chisholm; A Riecher-Rössler; P Falkai; C Pantelis; RKR Salokangas; R Lencer; A Bertolino; J Kambeitz; E Meisenzahl; S Borgwardt; P Brambilla; SJ Wood; R Upthegrove; F Schultze-Lutter; N Koutsouleris; DB Dwyer

Journal article

Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness

R Sanfelici, A Ruef, LA Antonucci, N Penzel, A Sotiras, MS Dong, M Urquijo-Castro, J Wenzel, L Kambeitz-Ilankovic, MD Hettwer, S Ruhrmann, K Chisholm, A Riecher-Rössler, P Falkai, C Pantelis, RKR Salokangas, R Lencer, A Bertolino, J Kambeitz, E Meisenzahl Show all

Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2022

DOI: 10.1093/cercor/bhab288

Abstract

Adult gyrification provides a window into coordinated early neurodevelopment when disruptions predispose individuals to psychiatric illness. We hypothesized that the echoes of such disruptions should be observed within structural gyrification networks in early psychiatric illness that would demonstrate associations with developmentally relevant variables rather than specific psychiatric symptoms. We employed a new data-driven method (Orthogonal Projective Non-Negative Matrix Factorization) to delineate novel gyrification-based networks of structural covariance in 308 healthy controls. Gyrification within the networks was then compared to 713 patients with recent onset psychosis or depression..

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University of Melbourne Researchers

Christos Pantelis Author

Stephen Wood Author

Dom Dwyer Author

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Grants

Awarded by PRONIA: a Collaboration Project - European Union under the 7th Framework Program

Awarded by Max Planck Society

Awarded by Italian Minister of Education (Attraction and International Mobility-AIM-action)

Awarded by NIH/NIA

Awarded by National Health and Medical Research Council Senior Principal Research Fellowship

Awarded by European Union-National Health and Medical Research Council

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by PRONIA: a Collaboration Project funded by the European Union under the 7th Framework Program under grant agreement number 602152. BMBF and Max Planck Society (grant agreement number M526300) funded R.S. Structural European Funding of the Italian Minister of Education (Attraction and International Mobility-AIM-action, grant agreement No 1859959) funded L.A.A. NIH/NIA supported A.S. (grant R01AG06710). National Health and Medical Research Council Senior Principal Research Fellowship (grants 628386 and 1105825) and European Union-National Health and Medical Research Council (grant 1075379) supported C.P., S.R., A.R-R., and N.K. reported receiving grants from the European Union (EU) during the conduct of the study.